Novartis Animal Health
Pharmacology

CAPSTAR

CAPSTAR™ (nitenpyram) is an oral tablet for dogs, puppies, cats and kittens 4 weeks of age and older and 2 pounds of body weight or greater.

ACTIVE INGREDIENTS

CAPSTAR Tablets contain 11.4 or 57.0 mg of nitenpyram, which belongs to the chemical class of neonicotinoids. Nitenpyram kills adult fleas.

WARNINGS

Not for human use. Keep this and all drugs out of the reach of children.

DIRECTIONS

CAPSTAR (nitenpyram) Tablets are for the treatment of flea infestations on dogs, puppies, cats and kittens 4 weeks of age and older and 2 pounds of body weight or greater.

CAPSTAR Tablets may be used as needed, as often as once per day, whenever you see fleas on your pet. To give CAPSTAR Tablets, place the pill directly in your pet's mouth, or hide it in food. If you hide the pill in food, watch closely to make sure your pet swallows the pill. If you are not sure that your pet swallowed the pill, it is safe to give a second pill. Treat all infested pets in the household. Fleas can reproduce on untreated pets and allow infestations to persist.

DOSAGE

CAPSTAR (nitenpyram) Tablets should be administered according to the following schedule:

WEIGH YOUR PET PRIOR TO ADMINISTRATION TO ENSURE PROPER DOSAGE.

Do not administer to pets under 2 pounds.

RECOMMENDED DOSAGE SCHEDULE

Species Body Weight Dose Nitenpyram Per Tablet
Dog or Cat...............2-25 lbs.................One tablet...............11.4 mg
Dog.....................25.1-125 lbs..............One tablet...............57.0 mg

ADVERSE REACTIONS

Laboratory and clinical studies showed that CAPSTAR Tablets are safe for use in dogs, cats, puppies and kittens 4 weeks of age and older and 2 pounds of body weight or greater.

OTHER INFORMATION

CAPSTAR (nitenpyram) begins working within 30 minutes. In studies, CAPSTAR achieved greater than 90% effectiveness against adult fleas on dogs within 4 hours and cats within 6 hours.

CAPSTAR Tablets are safe for pregnant or nursing dogs and cats.

When using this product, you may notice that your dog or cat will start scratching itself as fleas begin to die. The scratching behavior is temporary and is a reaction to the fleas, not the drug.

CAPSTAR Tablets kill adult fleas that cause flea allergy dermatitis (FAD).

CAPSTAR Tablets may be used together with other products including heartworm preventives, corticosteroids, antibiotics, vaccines, deworming medications, shampoos and other flea products.

FLEA INFESTATIONS ON DOGS AND CATS

In addition to the common nuisance irritations associated with infestations, fleas can be responsible for skin conditions in your pet such as flea allergy dermatitis (FAD) in dogs and miliary dermatitis in cats. Also, fleas transmit other parasites, including tapeworms. The control of flea infestations is important to your pet's health and also reduces the problems associated with these parasites.

CAPSTAR (nitenpyram) Tablets do not have an effect on fleas in the pet's environment. You may need to treat more than one time, because immature fleas in and around the home will continue to develop into adults that can reinfest your pet.

Alternatively, you can treat your pet or environment with an insect growth regulator, or you can treat your pet with an insect development inhibitor. Both insect growth regulators and insect development inhibitors act by preventing the development of immature stages of the flea. This will prevent fleas from reinfesting your pet. Laboratory studies have shown that CAPSTAR Tablets can be used safely with lufenuron.

The following diagram illustrates the flea's life cycle and where CAPSTAR Tablets work.

LIFE CYCLE OF THE FLEA

Fleas can be a problem because they reproduce so rapidly. A single female flea may produce up to 2,000 eggs over her lifetime. Eggs hatch and can develop into adults within only three weeks. Adult female fleas feed by ingesting blood from your pet and subsequently lay eggs, which drop off your pet's coat. Within days, larvae hatch from the eggs and live undetected in your pet's surroundings, such as the carpet, bedding and other protected areas. Flea larvae spin a cocoon, and when appropriately stimulated, a young adult flea emerges and jumps onto your pet to continue the life cycle. When these new fleas are seen on your pet, treat with CAPSTAR (nitenpyram) Tablets.

After reading this insert if you have any questions about flea control or medical problems associated with flea populations, consult your veterinarian, who is your pet's health care expert.

STORAGE CONDITIONS

Store at controlled room temperature, between 59° and 86°F (15-30°C).

Questions? Comments? Please call 1-888-327-9745.

Manufactured for:
Novartis Animal Health US, Inc.
Greensboro, NC 27408

NADA # 141-175, Approved by FDA
Patent # 5,750,548

©2000 Novartis
NAH/CAP-DT/PI/1 08/00